Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 13/20 | 0.77 |
| ▸ | MAPK9 | P45984 | 13/20 | 0.77 |
| ▸ | MAPK10 | P53779 | 13/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712247 | 0.87 | MAPK8 (0.78) | MAPK8MAPK9MAPK10MAPTCYP1A2 | |
| SCHEMBL3714731 | 0.84 | MAPK8 (1.00) | MAPK8MAPK9MAPK10MAPTCYP1A2 | |
| SCHEMBL14780538 | 0.82 | MAPK8 (0.78) | MAPK8MAPK9MAPK10MAPTCYP3A4 | |
| SCHEMBL3713959 | 0.81 | MAPK8 (0.77) | MAPK8MAPK9MAPK10MAPTPOLB | |
| SCHEMBL9049807 | 0.80 | CYP1A2 (0.56) | MAPK8MAPK9MAPK10MAPTCYP1A2 | |
| SCHEMBL1077995 | 0.77 | MAPT (0.77) | MAPK8MAPK9MAPK10MAPTCYP1A2 | |
| SCHEMBL23413572 | 0.77 | NPC1 (0.76) | MAPK8MAPK9MAPK10MAPTCYP1A2 | |
| SCHEMBL13040502 | 0.77 | MAPK8 (0.60) | MAPK8MAPK9MAPK10MAPTPOLB | |
| SCHEMBL3714662 | 0.76 | MAPK8 (0.80) | MAPK8MAPK9MAPK10HTT | |
| SCHEMBL30216491 | 0.75 | ALDH1A1 (0.63) | MAPK8MAPK9MAPK10MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915150-B1 | USE OF THIENOPYRIDONE DERIVATIVES AS AMPK ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | disclosed |
| US-20090105293-A1 | USE OF THIENOPYRIDONE DERIVATIVES AS AMPK ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK PATENT GESELLSCHAFT (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1754483-A1 | Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them | Merck Sante (FR) | 2007-02-21 | — | — | EP | disclosed |
| US-5602144-A | ADMINISTERING FOR TREATMENT OF CEREBRAL ISCHAEMIA OR SCHIZOPHRENIA | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105293-A1 | USE OF THIENOPYRIDONE DERIVATIVES AS AMPK ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PRKAR2A, PRKAR2B, PRKAB1 | MAPK8 2113/4885MAPK9 1187/4885MAPK10 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.