Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.51 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 0.50 |
| ▸ | IFNAR1 | P17181 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10411043 | 0.98 | HTR1B (0.50) | HTR1BNR2E1IFNAR1SIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11283634 | 0.76 | HTR1B (0.50) | HTR1BIFNAR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL13601938 | 0.76 | HTR1A (0.43) | HTR1BNR2E1HTR1AADRA1ACACNA2D1 | |
| SCHEMBL2607777 | 0.75 | IFNAR1 (0.45) | IFNAR1ALDH1A1LMNACYP1A2MAPK1 | |
| SCHEMBL6293960 | 0.75 | IFNAR1 (0.43) | IFNAR1ALDH1A1LMNACYP1A2MAPK1 | |
| SCHEMBL2117027 | 0.74 | IFNAR1 (0.44) | IFNAR1ALDH1A1LMNACYP1A2MAPK1 | |
| SCHEMBL2607673 | 0.73 | TLR8 (0.50) | HTR1BIFNAR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL10409466 | 0.72 | CNR2 (0.50) | HTR1BNR2E1CYP1A2CYP2D6TSHR | |
| SCHEMBL10409411 | 0.72 | BCL2L1 (0.35) | SIGMAR1ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL1493101 | 0.72 | ALDH1A1 (0.44) | IFNAR1ALDH1A1LMNACYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4895840-A | ANTIARRHYTHMIA AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0295010-A1 | Derivatives of alkylaminoalkyl ureas and cyanoguanidines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-12-14 | — | — | EP | disclosed |
| US-4724235-A | N-(arylthioalkyl)-N'-(aminoalkyl)ureas useful in the treatment of arrhythmia | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-02-09 | — | — | US | disclosed |
| US-4597902-A | TREATMENT OF CARDIAC ARRHYTHMIAS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-07-01 | — | — | US | disclosed |
| EP-0066415-B1 | N-(ARYLTHIOALKYL)-N'-(AMINOALKYL)UREAS | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0066415-A2 | N-(arylthioalkyl)-N'-(aminoalkyl)ureas | A.H. ROBINS COMPANY, INCORPORATED (US) | 1982-12-08 | — | — | EP | disclosed |