Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.64 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616232 | 0.80 | HRH4 (0.72) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL5788921 | 0.80 | CRHBP (0.96) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL24313224 | 0.78 | CRHBP (1.00) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL6600071 | 0.78 | CRHBP (1.00) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL5742555 | 0.78 | MAPT (0.97) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL5791898 | 0.76 | MAPT (0.68) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL1617816 | 0.76 | HRH4 (0.72) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL5789932 | 0.76 | CRHBP (1.00) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL2166349 | 0.75 | HRH4 (0.84) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL5788914 | 0.75 | HRH4 (0.73) | CRHBPCRHR2SMN1; SMN2MAPTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4980350-A | Piperazinylalkylpyrimidines as hypoglycemic agents | MERCK & CO., INC. (US) | 1990-12-25 | — | — | US | disclosed |
| EP-0330263-A1 | Piperazinylalkylpyrimidines as hypoglycemic agents | MERCK & CO. INC. (US) | 1989-08-30 | — | — | EP | disclosed |