Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | CRHBP | P24387 | 2/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789359 | 0.85 | CRHBP (0.64) | MAPTGFERSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL5742555 | 0.82 | MAPT (0.97) | MAPTGFERSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL5788789 | 0.79 | CRHBP (0.60) | MAPTGFERSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL27886711 | 0.78 | HRH3 (0.66) | MAPTDHFRHRH3ALDH1A1HRH4 | |
| SCHEMBL5030785 | 0.78 | RAB9A (0.63) | MAPTSMN1; SMN2KDM4EHPGDTSHR | |
| SCHEMBL1616232 | 0.78 | HRH4 (0.72) | MAPTGFERSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL5788921 | 0.77 | CRHBP (0.96) | MAPTGFERSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL5790678 | 0.77 | HRH4 (0.54) | MAPTGFERSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL15800694 | 0.77 | PLD1 (0.73) | MAPTSMN1; SMN2KDM4EHPGDTSHR | |
| SCHEMBL21353591 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006016014-A1 | NOVEL COMPOUNDS OF A 6-METHYL-PYRIMIDINE-2,4-DIAMINE FAMILY, METHOD FOR SYNTHESISING, COMPOSITIONS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | L'OREAL (FR) | 2006-02-16 | — | — | WO | claimed |
| EP-1437348-A1 | 6-methyl-2,4-diamino-pyrimidine derivatives, process for preparation, compositions containing them and their uses as basic neutralising agents | L'OREAL (FR) | 2004-07-14 | — | — | EP | claimed |
| WO-2006016014-A1 | NOVEL COMPOUNDS OF A 6-METHYL-PYRIMIDINE-2,4-DIAMINE FAMILY, METHOD FOR SYNTHESISING, COMPOSITIONS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | L'OREAL (FR) | 2006-02-16 | — | — | WO | disclosed |
| EP-1437348-A1 | 6-methyl-2,4-diamino-pyrimidine derivatives, process for preparation, compositions containing them and their uses as basic neutralising agents | L'OREAL (FR) | 2004-07-14 | — | — | EP | disclosed |