SCHEMBL10411978

SCHEMBL10411978

NC(=O)CC1=Cc2ccccc2OC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 6/20 0.48
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
KMT2A Q03164 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
MAPT P10636 3/20 0.43
MEN1 O00255 2/20 0.43
NFKB1 P19838 2/20 0.43
NFKB2 Q00653 2/20 0.43
RELA Q04206 2/20 0.43
CASP3 P42574 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
PTGS1 P23219 4/20 0.42
PTGS2 P35354 4/20 0.42
ALOX12 P18054 1/20 0.42
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 3/20 0.41
MAOB P27338 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8665718 0.85 ALOX5 (0.49) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL9731627 0.77 ALOX5 (0.46) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL30529006 0.77 ALOX5 (0.46) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL545827 0.76 ALOX5 (0.62) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL31560392 0.76 ALOX5 (0.62) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL27471696 0.75 ALOX5 (0.47) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL27800748 0.75 HTR1A (0.43) MAOBMAOA
SCHEMBL14306683 0.74 ALOX5 (0.41) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL30629156 0.73 ALOX5 (0.41) ALOX5NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL7294523 0.73 ALOX5 (0.42) ALOX5NPC1RAB9AKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4868205-A ANTIALLERGENS, ANTIINFLAMMATORY, CARDIOVASCULAR DISORDERS WARNER-LAMBERT COMPANY (US) 1989-09-19 US claimed
US-4921871-A LIPOXYGENASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1990-05-01 US disclosed
US-4874758-A LIPOXYGENASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1989-10-17 US disclosed
US-4868200-A LEUKOTRIENES, LIPOXYGENASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1989-09-19 US disclosed
US-4868195-A ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY WARNER-LAMBERT COMPANY (US) 1989-09-19 US disclosed
US-4868205-A ANTIALLERGENS, ANTIINFLAMMATORY, CARDIOVASCULAR DISORDERS WARNER-LAMBERT COMPANY (US) 1989-09-19 US disclosed
US-4868199-A ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY WARNER-LAMBERT COMPANY (US) 1989-09-19 US disclosed
US-4761424-A Enolamides, pharmaceutical compositions and methods for treating inflammation WARNER-LAMBERT COMPANY (US) 1988-08-02 US disclosed
EP-0221345-A1 Novel enolamides, process for their manufacture and pharmaceutical compositions thereof with an activity as modulators of the arachidonic acid cascade WARNER-LAMBERT COMPANY (US) 1987-05-13 EP disclosed