Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10413272 | 1.00 | HTR1A (0.51) | HTR1AHTR1BDRD2DRD4DRD3 | |
| SCHEMBL10413753 | 1.00 | HTR1A (0.51) | HTR1AHTR1BDRD2DRD4DRD3 | |
| SCHEMBL10412539 | 1.00 | HTR1A (0.51) | HTR1AHTR1BDRD2DRD4DRD3 | |
| SCHEMBL10413237 | 1.00 | HTR1A (0.51) | HTR1AHTR1BDRD2DRD4DRD3 | |
| SCHEMBL10414180 | 1.00 | HTR1A (0.51) | HTR1AHTR1BDRD2DRD4DRD3 | |
| SCHEMBL10414153 | 0.94 | DRD2 (0.43) | HTR1AHTR1BDRD2DRD4DRD3 | |
| SCHEMBL10413746 | 0.90 | HTR1A (0.48) | HTR1AHTR1BDRD2DRD4DRD3 | |
| SCHEMBL10413248 | 0.88 | HTR1A (0.58) | HTR1AHTR1B | |
| SCHEMBL10414181 | 0.88 | HTR1A (0.58) | HTR1AHTR1B | |
| SCHEMBL10412926 | 0.88 | HTR1A (0.58) | HTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |