Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | SNCA | P37840 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | CD74 | P04233 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086002 | 0.90 | HTR2C (0.55) | HTR6APPSNCAHTR2CHTR2A | |
| SCHEMBL9584191 | 0.87 | APP (0.53) | HTR6APPSNCAHTR2CHTR2A | |
| Quinoline SCHEMBL28080464 | 0.85 | HTR6 (0.52) | HTR6APPSNCAHTR2CHTR2A | |
| SCHEMBL6087849 | 0.85 | MAPT (0.53) | HTR6HTR2CHTR2ABRD4PTGDR2 | |
| SCHEMBL6086419 | 0.84 | HTR2C (0.54) | HTR6HTR2CHTR2ABRD4PTGDR2 | |
| SCHEMBL6086069 | 0.81 | CCR2 (0.54) | HTR6HTR2CHTR2ABRD4PTGDR2 | |
| SCHEMBL28101302 | 0.81 | HTR6 (0.60) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL6086525 | 0.80 | CYP11B1 (0.48) | HTR6APPSNCAHTR2CHTR2A | |
| SCHEMBL4943583 | 0.80 | HTR6 (0.58) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL5134071 | 0.80 | HTR6 (0.66) | HTR6APPSNCABRD4BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-110526903-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2021-12-10 | — | — | CN | disclosed |
| CN-110526903-A | Bisindole maleimide derivative and its preparation method and application | OCEAN UNIV CHINA | 2019-12-03 | — | — | CN | disclosed |
| CN-110218206-A | Bisindole maleimide derivative and its preparation method and application | 中国海洋大学 | 2019-09-10 | — | — | CN | disclosed |
| CN-106083830-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2019-07-12 | — | — | CN | disclosed |
| CN-106146475-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2019-05-17 | — | — | CN | disclosed |
| CN-106146475-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106083830-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-09 | — | — | CN | disclosed |
| US-4895958-A | CHROMOGENS, IMAGES, PRESSURE SENSITIVE AND HEAT RESPONSIVE CARBONLESS DUPLICATING | HILTON DAVIS CO. (US) | 1990-01-23 | — | — | US | disclosed |
| US-4795736-A | AMINOPHENYL PHENYLSULFONYL PROPENE/1-/ | HILTON DAVIS CO. (US) | 1989-01-03 | — | — | US | disclosed |
| US-4403791-A | Carbonless duplicating and marking systems | STERLING DRUG INC. (US) | 1983-09-13 | — | — | US | disclosed |
| US-4377698-A | 2,4 Bis(2-indolyl-3)-4-oxobutanoic acids | STERLING DRUG INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4351768-A | CARBONLESS, DUPLICATION, INDOLE DYES | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4322352-A | Indolyl phthalide compounds | STERLING DRUG INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4307018-A | CHROMOGENS FOR COPYING SYSTEMS | STERLING DRUG INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4275121-A | Carbonless duplicating and marking systems utilizing indolyl-substituted furanone color formers | STERLING DRUG INC. (US) | 1981-06-23 | — | — | US | disclosed |
| US-4257954-A | INDOLYL-PHENYLSULFONYL-PHENYL METHANE | STERLING DRUG INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4251446-A | COLOR PRECURSORS | STERLING DRUG INC. (US) | 1981-02-17 | — | — | US | disclosed |
| US-4189171-A | PRESSURE SENSITIVE, THERMAL AND HECTOGRAPHIC SYSTEMS | STERLING DRUG INC. (US) | 1980-02-19 | — | — | US | disclosed |
| US-4075224-A | 3,5-Bis (indolyl)-5-(indolyl)-2(5H)-furanones | STERLING DRUG INC. (US) | 1978-02-21 | — | — | US | disclosed |