Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.66 |
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | SNCA | P37840 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 3/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396279 | 1.00 | HTR6 (0.66) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL30241534 | 0.87 | HTR6 (0.66) | HTR6APPSNCAPLAUSLC2A1 | |
| SCHEMBL2769024 | 0.87 | HTR6 (0.66) | HTR6APPSNCAPLAUSLC2A1 | |
| SCHEMBL1122491 | 0.84 | NOS1 (0.52) | HTR6KMT2A | |
| SCHEMBL916458 | 0.82 | HTR6 (0.51) | HTR6PLAUKMT2AKDM4C | |
| SCHEMBL24414631 | 0.82 | HTR6 (0.57) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL28101302 | 0.81 | HTR6 (0.60) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL710269 | 0.81 | HTR6 (0.50) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL17602070 | 0.80 | BACE1 (0.61) | HTR6APPSNCABRD4BACE1 | |
| SCHEMBL4943583 | 0.80 | HTR6 (0.58) | HTR6APPSNCABRD4BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489659-A1 | Modulators of ATP-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-1974212-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | Vertex Pharmaceuticals Incorporated (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007075946-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |