Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRB | O95718 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | GLI1 | P08151 | 1/20 | 0.44 |
| ▸ | GLI2 | P10070 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421103 | 0.92 | CYP4F2 (0.49) | ESRRBCYP4F2CYP4A11CYP19A1STS | |
| SCHEMBL10421932 | 0.86 | HSP90AB1 (0.50) | ESRRBCYP4F2CYP4A11CYP19A1STS | |
| SCHEMBL3469156 | 0.85 | MAPT (0.50) | ESRRBCYP4F2CYP4A11HTTSMN1; SMN2 | |
| SCHEMBL16035191 | 0.82 | CYP4F2 (0.52) | CYP4F2CYP4A11 | |
| SCHEMBL3530979 | 0.81 | CYP4F2 (0.54) | CYP4F2CYP4A11SIRT2SMN1; SMN2 | |
| SCHEMBL27399582 | 0.81 | CYP4F2 (0.54) | CYP4F2CYP4A11SIRT2LOXL2 | |
| SCHEMBL31455819 | 0.81 | CYP4F2 (0.54) | CYP4F2CYP4A11SIRT2SMN1; SMN2 | |
| SCHEMBL30655576 | 0.81 | SPR (0.57) | CYP4F2CYP4A11SIRT2 | |
| SCHEMBL1124591 | 0.81 | SPR (0.57) | CYP4F2CYP4A11SIRT2 | |
| SCHEMBL435228 | 0.80 | FFAR1 (0.57) | HTTSMN1; SMN2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |