Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.49 |
| ▸ | ESRRB | O95718 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | GLI1 | P08151 | 2/20 | 0.42 |
| ▸ | GLI2 | P10070 | 2/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10420236 | 0.92 | ESRRB (0.50) | CYP4F2CYP4A11ESRRBCYP19A1GLI1 | |
| SCHEMBL16035191 | 0.91 | CYP4F2 (0.52) | CYP4F2CYP4A11TDP1 | |
| SCHEMBL10421932 | 0.83 | HSP90AB1 (0.50) | CYP4F2CYP4A11ESRRBCYP19A1STS | |
| SCHEMBL28151357 | 0.82 | HDAC6 (0.57) | CYP4F2CYP4A11 | |
| SCHEMBL16091085 | 0.80 | TDP1 (0.51) | CYP4A11ESRRBSRD5A2TDP1SMN1; SMN2 | |
| SCHEMBL10420338 | 0.79 | CYP4F2 (0.63) | CYP4F2CYP4A11MIFDPP4TDP1 | |
| SCHEMBL1863579 | 0.78 | CALM1 (0.55) | CYP4F2CYP4A11CYP19A1MIFPLAAT3 | |
| SCHEMBL3469156 | 0.77 | MAPT (0.50) | CYP4F2CYP4A11ESRRBSRD5A2HTT | |
| SCHEMBL16035296 | 0.77 | MGLL (0.47) | TDP1 | |
| SCHEMBL10421744 | 0.76 | STS (0.51) | ESRRBSTSSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |