Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | ESRRB | O95718 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6115593 | 0.89 | SLC7A5 (0.55) | HSP90AB1CYP19A1SLC7A5ALDH1A1GAA | |
| SCHEMBL11445117 | 0.87 | HPGD (0.47) | SLC7A5ALDH1A1GAAGFERHTT | |
| SCHEMBL10420236 | 0.86 | ESRRB (0.50) | CYP19A1ESRRBSTSHTTSMN1; SMN2 | |
| SCHEMBL27661252 | 0.84 | CYP4F2 (0.56) | HSP90AB1ALDH1A1GAAGFERHTT | |
| SCHEMBL10421103 | 0.83 | CYP4F2 (0.49) | CYP19A1ESRRBSTSHTTSMN1; SMN2 | |
| SCHEMBL9427627 | 0.81 | CYP19A1 (0.53) | CYP19A1HTTSRD5A2LMNAMAPT | |
| SCHEMBL479999 | 0.80 | SLC7A5 (0.57) | SLC7A5SMN1; SMN2LOXL2PKMRAB9A | |
| SCHEMBL2964543 | 0.80 | LOXL2 (0.68) | SLC7A5ALDH1A1GAAGFERSMN1; SMN2 | |
| SCHEMBL8057216 | 0.80 | SLC7A5 (0.57) | HSP90AB1SLC7A5ALDH1A1GAAGFER | |
| SCHEMBL30489978 | 0.80 | SLC7A5 (0.57) | SLC7A5SMN1; SMN2LOXL2PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |