Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CPA1 | P15085 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10709091 | 0.91 | REN (0.39) | REN | |
| SCHEMBL10422492 | 0.90 | REN (0.48) | REN | |
| SCHEMBL10421139 | 0.82 | REN (0.52) | REN | |
| SCHEMBL10421337 | 0.78 | REN (0.49) | REN | |
| SCHEMBL10422706 | 0.77 | REN (0.48) | REN | |
| SCHEMBL8484478 | 0.76 | MMP9 (0.47) | RENCTSSMMEACECPA1 | |
| SCHEMBL8484484 | 0.76 | MMP9 (0.47) | RENCTSSMMEACECPA1 | |
| SCHEMBL10422425 | 0.76 | REN (0.45) | RENCTSS | |
| SCHEMBL10421231 | 0.76 | REN (0.46) | REN | |
| SCHEMBL10420913 | 0.75 | REN (0.46) | RENLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904660-A | HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |
| EP-0281316-A2 | Renin inhibitors | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |