Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421180 | 0.85 | CTSS (0.42) | REN | |
| SCHEMBL10714989 | 0.82 | LNPEP (0.32) | — | |
| SCHEMBL10420912 | 0.80 | REN (0.58) | REN | |
| SCHEMBL7305156 | 0.76 | REN (0.65) | REN | |
| SCHEMBL10421141 | 0.75 | REN (0.42) | RENLTA4H | |
| SCHEMBL8909404 | 0.75 | REN (0.62) | REN | |
| SCHEMBL7268382 | 0.74 | REN (0.46) | REN | |
| SCHEMBL10422486 | 0.74 | LNPEP (0.35) | — | |
| SCHEMBL7303652 | 0.73 | REN (0.57) | REN | |
| SCHEMBL9800511 | 0.72 | REN (0.55) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904660-A | HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |
| EP-0281316-A2 | Renin inhibitors | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |