Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.40 |
| ▸ | IL1RN | P18510 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422428 | 0.93 | HRH4 (0.47) | ERAP2ERAP1IL1RNHRH4MME | |
| SCHEMBL10421546 | 0.90 | HRH4 (0.39) | ERAP2ERAP1IL1RNHRH4SCN9A | |
| SCHEMBL8486193 | 0.87 | HRH4 (0.45) | ERAP2ERAP1HRH4RENMME | |
| SCHEMBL8486197 | 0.87 | HRH4 (0.45) | ERAP2ERAP1HRH4RENMME | |
| SCHEMBL10422014 | 0.86 | REN (0.53) | SCN9AREN | |
| SCHEMBL10520319 | 0.82 | HRH4 (0.44) | ERAP2ERAP1HRH4RENMMP9 | |
| SCHEMBL10421238 | 0.81 | REN (0.44) | REN | |
| SCHEMBL10422431 | 0.78 | REN (0.51) | HRH4SCN9ARENMMEPIN1 | |
| SCHEMBL7380910 | 0.78 | KMT2A (0.45) | KMT2A | |
| SCHEMBL8481399 | 0.78 | HRH4 (0.56) | HRH4MEN1KMT2AMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904660-A | HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |
| EP-0281316-A2 | Renin inhibitors | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |