Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.45 |
| ▸ | NLN | Q9BYT8 | 2/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422431 | 0.93 | REN (0.51) | RENSCN9AFNTAPGGT1B | |
| SCHEMBL10422012 | 0.86 | ERAP2 (0.40) | RENSCN9A | |
| SCHEMBL10520328 | 0.82 | REN (0.54) | RENNLNFNTAPGGT1B | |
| SCHEMBL10422428 | 0.78 | HRH4 (0.47) | — | |
| SCHEMBL7380911 | 0.78 | ITGB2 (0.51) | RENNLNPDCD1CD274 | |
| SCHEMBL10522368 | 0.77 | REN (0.54) | RENFNTAPGGT1B | |
| SCHEMBL10421546 | 0.76 | HRH4 (0.39) | RENSCN9A | |
| SCHEMBL7381945 | 0.76 | REN (0.71) | RENNLNFNTAPGGT1B | |
| SCHEMBL7386111 | 0.74 | REN (0.48) | RENPDCD1CD274 | |
| SCHEMBL10420797 | 0.73 | CTNNB1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904660-A | HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |
| EP-0281316-A2 | Renin inhibitors | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |