Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.39 |
| ▸ | ITGAV | P06756 | 5/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.39 |
| ▸ | IL1RN | P18510 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421546 | 0.93 | HRH4 (0.39) | HRH4PIN1MMEACECPA1 | |
| SCHEMBL10422012 | 0.93 | ERAP2 (0.40) | HRH4PIN1MMEACECPA1 | |
| SCHEMBL8481399 | 0.85 | HRH4 (0.56) | HRH4PIN1MMEACECPA1 | |
| SCHEMBL8481408 | 0.85 | HRH4 (0.56) | HRH4PIN1MMEACECPA1 | |
| SCHEMBL8481892 | 0.85 | HRH4 (0.56) | HRH4PIN1MMEACECPA1 | |
| SCHEMBL10422431 | 0.85 | REN (0.51) | HRH4PIN1MME | |
| SCHEMBL8481391 | 0.82 | HRH4 (0.64) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481380 | 0.82 | HRH4 (0.64) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10421548 | 0.82 | HRH4 (0.43) | HRH4PIN1MMEACECPA1 | |
| SCHEMBL10420797 | 0.80 | CTNNB1 (0.44) | HRH4PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904660-A | HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |
| EP-0281316-A2 | Renin inhibitors | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |