Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422237 | 0.82 | SLC2A1 (0.50) | SLC2A1ADRB2ADRB1KCNH2SLC6A2 | |
| SCHEMBL10422891 | 0.81 | ADRB2 (0.38) | ADRB2ALDH1A1ADRB1KDM4ENR1I2 | |
| SCHEMBL9742772 | 0.77 | ALDH1A1 (0.43) | SLC2A1ADRB2ALDH1A1ADRB1KCNH2 | |
| SCHEMBL10422909 | 0.77 | ADRB2 (0.50) | SLC2A1ADRB2ALDH1A1ADRB1KCNH2 | |
| SCHEMBL9741554 | 0.77 | SLC2A1 (0.49) | SLC2A1ADRB2ALDH1A1ADRB1KCNH2 | |
| SCHEMBL13799302 | 0.75 | ADRB2 (0.63) | ADRB2ADRB1KCNH2LMNASLC6A2 | |
| SCHEMBL31010972 | 0.75 | ADRB2 (0.63) | ADRB2ADRB1KCNH2LMNASLC6A2 | |
| Picumeterol SCHEMBL83175 | 0.72 | SLC2A1 (0.57) | SLC2A1ADRB2ADRB1KCNH2SLC6A2 | |
| Picumeterol SCHEMBL156907 | 0.72 | SLC2A1 (0.57) | SLC2A1ADRB2ADRB1KCNH2SLC6A2 | |
| SCHEMBL10416913 | 0.72 | SLC2A1 (0.57) | SLC2A1ADRB2ADRB1KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959381-A | ADRENERGIC STIMULANTS | GLAXO GROUP LIMITED (GB) | 1990-09-25 | — | — | US | disclosed |
| EP-0278727-A2 | 1-(4-Amino-3-chloro-5-trifluoromethylphenyl)-2-(substituted amino)ethanol derivatives and their use in the treatment of respiratory disease | GLAXO GROUP LIMITED (GB) | 1988-08-17 | — | — | EP | disclosed |