Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 4/20 | 0.36 |
| ▸ | MMP9 | P14780 | 4/20 | 0.36 |
| ▸ | MMP8 | P22894 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748105 | 0.99 | REN (0.43) | RENHRH4MMEACECPA1 | |
| SCHEMBL10421161 | 0.92 | REN (0.49) | RENHRH4PIN1MMP2MMP9 | |
| SCHEMBL10753464 | 0.89 | REN (0.48) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10751142 | 0.88 | REN (0.47) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10422508 | 0.88 | REN (0.52) | RENHRH4MMEACECPA1 | |
| Water SCHEMBL10422512 | 0.87 | REN (0.52) | RENHRH4MMEACECPA1 | |
| SCHEMBL10750427 | 0.84 | HRH4 (0.45) | RENHRH4MMEACECPA1 | |
| SCHEMBL10751443 | 0.84 | HRH4 (0.45) | RENHRH4MMEACECPA1 | |
| SCHEMBL8481892 | 0.83 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481399 | 0.83 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4656269-A | RENIN INHIBITORY EFFECT WHEN ADMINISTERING ORALLY; HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| EP-0200406-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |