Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL27674763 | 0.87 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4A | |
| Demannose SCHEMBL19691965 | 0.87 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4A | |
| Demannose SCHEMBL31412690 | 0.87 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4A | |
| Demannose SCHEMBL4226809 | 0.87 | LMNA (0.44) | LMNAL3MBTL1TDP1PDE4A | |
| Demannose SCHEMBL28513575 | 0.85 | LMNA (0.42) | LMNAL3MBTL1TDP1PDE4A | |
| Demannose SCHEMBL10423685 | 0.84 | LMNA (0.41) | LMNAL3MBTL1TDP1PDE4A | |
| SCHEMBL10489052 | 0.83 | MPI (0.39) | MPI | |
| SCHEMBL13564709 | 0.82 | LMNA (0.50) | LMNAL3MBTL1TDP1PDE4A | |
| SCHEMBL13564642 | 0.82 | LMNA (0.50) | LMNAL3MBTL1TDP1PDE4A | |
| SCHEMBL21419878 | 0.82 | LMNA (0.50) | LMNAL3MBTL1TDP1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963482-A | EXPRESSION VECTOR OF RECOMBINANT DNA AND PROMOTER; OXYGEN FOR REPRESSING AND FORMATE FOR INDUCING; ISOLATION FROM ESCHERICHIA OR SALMONELLA | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |