Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.44 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27599825 | 0.91 | ACHE (0.46) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL10427888 | 0.88 | ACHE (0.46) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL10426976 | 0.86 | ACHE (0.54) | ACHE | |
| SCHEMBL10700406 | 0.86 | NQO2 (0.46) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL4621209 | 0.82 | CYP24A1 (0.65) | ACHECYP26A1CYP24A1 | |
| SCHEMBL7171991 | 0.81 | HDAC6 (0.51) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL8535560 | 0.80 | CYP19A1 (0.62) | ACHEMTNR1AMTNR1B | |
| SCHEMBL7249948 | 0.77 | ACHE (0.64) | ACHECYP26A1CYP24A1 | |
| SCHEMBL10427929 | 0.77 | CDK8 (0.53) | ACHE | |
| SCHEMBL8531158 | 0.77 | KMT2A (0.48) | ACHENQO2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259782-B1 | NAPHTHALENE AND INDANE DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESSES FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-12-27 | — | — | EP | disclosed |
| EP-0259782-A1 | Naphthalene and indane derivatives, medicaments containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |