Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | PGR | P06401 | 6/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.53 |
| ▸ | USP2 | O75604 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | AR | P10275 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10804061 | 1.00 | CYP3A4 (0.53) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10798107 | 0.91 | PGR (0.54) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10427840 | 0.91 | PGR (0.54) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10623130 | 0.91 | NR3C1 (0.42) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10623139 | 0.91 | NR3C1 (0.42) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10798059 | 0.90 | PGR (0.49) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10427774 | 0.90 | PGR (0.49) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10427874 | 0.89 | CYP3A4 (0.56) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10427866 | 0.89 | CYP3A4 (0.56) | CYP3A4PGRNR3C1ADORA3USP2 | |
| SCHEMBL10427864 | 0.89 | CYP3A4 (0.56) | CYP3A4PGRNR3C1ADORA3USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100874-B1 | 6,16-DIMETHYL CORTICOIDS, THEIR PREPARATION AND THEIR USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-03-07 | — | — | EP | disclosed |
| US-4701451-A | Novel 6,16-dimethylcorticoids their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-10-20 | — | — | US | disclosed |
| US-4555507-A | Novel 6, 16-dimethylcorticoids, their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-11-26 | — | — | US | disclosed |
| EP-0100874-A2 | 6,16-Dimethyl corticoids, their preparation and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-02-22 | — | — | EP | disclosed |