Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 3/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.44 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL7557530 | 0.88 | GSR (0.50) | SLC7A5ANPEPRNPEPTHRBSLC1A3 | |
| Phenylalanine SCHEMBL723829 | 0.87 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL3691104 | 0.87 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL10428533 | 0.86 | ALPI (0.49) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL10428531 | 0.86 | ALPI (0.49) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Leucine SCHEMBL8513294 | 0.84 | SLC7A5 (0.57) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL8975267 | 0.84 | SLC7A5 (0.61) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL23152419 | 0.83 | SLC7A5 (0.67) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL3401559 | 0.83 | SLC7A5 (0.67) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL3401561 | 0.83 | SLC7A5 (0.67) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | claimed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | claimed |
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | disclosed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | disclosed |