Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | ARG1 | P05089 | 2/20 | 0.33 |
| ▸ | ARG2 | P78540 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL19692958 | 0.94 | GSR (0.44) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| SCHEMBL16225105 | 0.89 | GSR (0.50) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL8199478 | 0.89 | GSR (0.65) | GSRSLC1A2SLC1A3SLC1A1GRIK1 | |
| Phenylalanine SCHEMBL10428532 | 0.88 | ALPI (0.46) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL8885814 | 0.86 | GSR (0.48) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Alanine SCHEMBL4961214 | 0.86 | GSR (0.59) | GSRTHRBRNPEPTLR2ARG1 | |
| SCHEMBL9780155 | 0.85 | GSR (0.68) | GSRRNPEPTLR2ARG1ARG2 | |
| SCHEMBL2821897 | 0.85 | GSR (0.68) | GSRRNPEPTLR2ARG1ARG2 | |
| Lysine SCHEMBL10428793 | 0.85 | GSR (0.53) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL8740433 | 0.84 | GSR (0.51) | GSRTHRBRNPEPTLR2ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020034570-A1 | Cheese flavoring | SYMRISE GMBH & CO. KG (DE) | 2002-03-21 | — | — | US | disclosed |