Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.47 |
| ▸ | TUBB | P07437 | 3/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177364 | 0.85 | KMT2A (0.51) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10428832 | 0.84 | MEN1 (0.50) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10428912 | 0.81 | ALDH1A1 (0.44) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10622361 | 0.81 | MEN1 (0.49) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL7461875 | 0.80 | KMT2A (0.43) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10428879 | 0.79 | MEN1 (0.49) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10428846 | 0.79 | ABCG2 (0.46) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL9189943 | 0.79 | VCP (0.54) | ALDH1A1KMT2AMEN1TUBB4ATUBB | |
| SCHEMBL5691140 | 0.79 | HTT (0.43) | TPMTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10428906 | 0.78 | MAPK1 (0.47) | TPMTALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282898-A2 | Propiolophenone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-09-21 | — | — | EP | claimed |
| US-4929741-A | ANTISECRETORY AGENTS, GASTRIC JUICE, ANTIULCER AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1990-05-29 | — | — | US | disclosed |
| EP-0282898-A2 | Propiolophenone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-09-21 | — | — | EP | disclosed |