Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.48 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10961667 | 0.91 | CYP3A4 (0.60) | CYP3A4CYP2D6CYP2C19SMN1; SMN2HPGD | |
| SCHEMBL10961164 | 0.91 | SLC5A1 (0.50) | CYP3A4CYP2D6CYP2C19SMN1; SMN2HPGD | |
| SCHEMBL10959610 | 0.86 | ALDH1A1 (0.50) | CYP3A4CYP2D6CYP2C19HPGDKMT2A | |
| SCHEMBL10964975 | 0.86 | LMNA (0.51) | CYP3A4CYP2D6CYP2C19HPGDLMNA | |
| SCHEMBL10962644 | 0.85 | AKR1C4 (0.47) | CYP3A4CYP2D6CYP2C19SMN1; SMN2HPGD | |
| SCHEMBL10960966 | 0.85 | KMT2A (0.49) | CYP3A4CYP2C19SMN1; SMN2HPGDLMNA | |
| SCHEMBL10961929 | 0.84 | HSD17B10 (0.48) | SMN1; SMN2HPGDLMNAKMT2AMEN1 | |
| SCHEMBL11303954 | 0.84 | ALDH1A1 (0.52) | CYP3A4CYP2D6CYP2C19SMN1; SMN2HPGD | |
| SCHEMBL10962656 | 0.83 | CYP3A4 (0.46) | CYP3A4CYP2D6CYP2C19SMN1; SMN2HPGD | |
| SCHEMBL11297673 | 0.83 | KDM4E (0.52) | CYP3A4CYP2D6CYP2C19SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0051819-B1 | TETRA-SUBSTITUTED BENZENE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-02-13 | — | — | EP | claimed |
| EP-0051819-A2 | Tetra-substituted benzene derivatives, their preparation and pharmaceutical preparations containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-05-19 | — | — | EP | claimed |
| US-4956351-A | INCLUSION COMPLEXESOFVIRICIDES; RHINITIS; SUSTAINED RELEASE; NONIRRITATING TO MUCOUS MEMBRANE | JANSSEN PHARMACEUTICA N.V. FRAME-543 (BE) | 1990-09-11 | — | — | US | disclosed |
| EP-0051819-B1 | TETRA-SUBSTITUTED BENZENE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-02-13 | — | — | EP | disclosed |
| EP-0129747-A2 | Thiazolidine derivatives, their preparation and intermediates therefor, and pharmaceutical preparations | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-01-02 | — | — | EP | disclosed |
| EP-0051819-A2 | Tetra-substituted benzene derivatives, their preparation and pharmaceutical preparations containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-05-19 | — | — | EP | disclosed |