Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLA1 | P09884 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10961667 | 0.91 | CYP3A4 (0.60) | RXFP1MAPTKMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL11303954 | 0.89 | ALDH1A1 (0.52) | KDM4ERXFP1MAPTKMT2ACYP3A4 | |
| SCHEMBL11296938 | 0.87 | PTPN1 (0.62) | KDM4ETP53GAAMAPTKMT2A | |
| SCHEMBL5065562 | 0.86 | CYP3A4 (0.53) | KDM4EMAPTKMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL10962641 | 0.85 | ALDH1A1 (0.55) | KDM4EGAAMAPTKMT2ACYP3A4 | |
| SCHEMBL11303041 | 0.85 | CYP3A4 (0.48) | KDM4ETP53MAPTKMT2ACYP3A4 | |
| SCHEMBL11300786 | 0.85 | ALDH1A1 (0.57) | GAAKMT2ACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL10429402 | 0.83 | CYP3A4 (0.51) | KDM4ERXFP1TP53MAPTKMT2A | |
| SCHEMBL11299380 | 0.82 | MMP13 (0.62) | KDM4EKMT2ACYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL11292022 | 0.82 | PPARA (0.56) | TP53MAPTKMT2ACYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0051819-A2 | Tetra-substituted benzene derivatives, their preparation and pharmaceutical preparations containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-05-19 | — | — | EP | claimed |