Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015626 | 0.87 | ATM (0.68) | POLBATMALDH1A1THRBCYP2C9 | |
| SCHEMBL9508615 | 0.86 | POLB (0.66) | POLBATMBIRC2HDAC3HDAC4 | |
| SCHEMBL9505274 | 0.78 | BIRC2 (0.59) | POLBATMBIRC2HDAC3HDAC4 | |
| SCHEMBL22962429 | 0.78 | REN (0.61) | BIRC2SSTR3 | |
| SCHEMBL7264947 | 0.77 | NAALAD2 (0.60) | ALDH1A1L3MBTL1 | |
| SCHEMBL8432604 | 0.77 | NAALAD2 (0.60) | ALDH1A1L3MBTL1 | |
| SCHEMBL22962240 | 0.77 | BIRC2 (0.60) | BIRC2MMP2MMP1 | |
| SCHEMBL7267826 | 0.77 | TACR1 (0.56) | POLBATMALDH1A1L3MBTL1 | |
| SCHEMBL14666035 | 0.76 | HDAC3 (0.66) | POLBATMBIRC2HDAC3HDAC4 | |
| SCHEMBL23734347 | 0.75 | CTSS (0.62) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370382-A2 | Urea dipeptide derivatives with a renin-inhibiting activity, process to produce them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |