Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 4/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123415 | 0.88 | MAPT (0.55) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL6416513 | 0.83 | MAPT (0.49) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL20851318 | 0.81 | MAPT (0.58) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL7329813 | 0.79 | NQO1 (0.67) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL3182331 | 0.79 | HPGD (0.66) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL2231003 | 0.79 | TSHR (0.50) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL12306453 | 0.77 | MAPT (0.47) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL2312172 | 0.77 | SCN4A (0.52) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL940075 | 0.77 | MAPT (0.54) | MAPTHPGDPOLBXBP1CYP2C9 | |
| SCHEMBL7528014 | 0.77 | MAPT (0.47) | MAPTHPGDPOLBXBP1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220024871-A1 | METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C | ACADIA PHARMACEUTICALS INC. | 2022-01-27 | — | — | US | claimed |
| US-20200181087-A1 | METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM | ACADIA PHARMACEUTICALS INC. (US) | 2020-06-11 | — | — | US | claimed |
| CN-110156664-A | A kind of synthetic method of piperazine Ma Selin | 常州大学 | 2019-08-23 | — | — | CN | claimed |
| CN-108947891-A | The method for safely preparing a Mo Fanselin and its tartrate using triphosgene | 丽珠集团新北江制药股份有限公司 | 2018-12-07 | — | — | CN | claimed |
| EP-3325444-A1 | METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C | Acadia Pharmaceuticals Inc. (US) | 2018-05-30 | — | — | EP | claimed |
| WO-2017015272-A1 | METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C | ACADIA PHARMACEUTICALS INC. (US) | 2017-01-26 | — | — | WO | claimed |
| CN-109111385-B | 5-HT 2A Receptor inhibitor and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230143664-A1 | HETEROAROMATIC DERIVATIVES HAVING SEROTONIN RECEPTOR BINDING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2023-05-11 | — | — | US | disclosed |
| CN-115605202-A | Aromatic heterocyclic derivatives having serotonin receptor binding activity | 盐野义制药株式会社（JP） | 2023-01-13 | — | — | CN | disclosed |
| CN-109111385-A | 5-HT2AAcceptor inhibitor and its preparation method and application | 上海翰森生物医药科技有限公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-108395384-A | The green synthesis method of isocyanates | 辽宁科技学院 | 2018-08-14 | — | — | CN | disclosed |
| CN-101657434-B | Process for production of polymers with iron complex catalyst | DAINIPPON INK & CHEMICALS | 2013-11-06 | — | — | CN | disclosed |
| EP-2269995-B1 | PROCESS FOR PRODUCTION OF POLYMERS WITH IRON COMPLEX CATALYST | DAINIPPON INK & CHEMICALS (JP) | 2012-12-12 | — | — | EP | disclosed |
| US-5306808-A | Endothelin derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0547317-A1 | Endothelin antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-23 | — | — | EP | disclosed |
| EP-0499266-A1 | Endothelin antagonist | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-08-19 | — | — | EP | disclosed |
| EP-0470256-A1 | PEPTIDE DERIVATIVES AND PRODUCTION THEREOF | Takeda Chemical Industries, Ltd. (JP) | 1992-02-12 | — | — | EP | disclosed |
| WO-1991013089-A1 | PEPTIDE DERIVATIVES AND PRODUCTION THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-09-05 | — | — | WO | disclosed |
| US-4285961-A | MICROBIOCIDES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-08-25 | — | — | US | disclosed |
| EP-0015639-A2 | Enantiomers of triazole compounds, a process for preparing them, their use as plant fungicides and growth regulating agents and compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-09-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230143664-A1 | HETEROAROMATIC DERIVATIVES HAVING SEROTONIN RECEPTOR BINDING ACTIVITY | HTR1A, HTR7, HTR2A | MAPT 4324/4885HPGD 4350/4885POLB 3292/4885 |
| US-20220024871-A1 | METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C | NR3C2, NR2C2, CYP4A22 | MAPT 4837/4885HPGD 4204/4885POLB 1353/4885 |
| US-20200181087-A1 | METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM | NR3C2, NR2C2, CYP4A22 | MAPT 4854/4885HPGD 3880/4885POLB 1249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.