Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14195569 | 0.85 | CYP3A4 (0.56) | LMNADCTPP1ALDH1A1MAPTBCHE | |
| SCHEMBL10432075 | 0.84 | ALDH1A1 (0.56) | LMNAALDH1A1MAPTCYP11B2SMN1; SMN2 | |
| SCHEMBL10432253 | 0.84 | ALDH1A1 (0.45) | LMNAALDH1A1MAPTBCHECYP11B2 | |
| SCHEMBL1104386 | 0.81 | ALDH1A1 (0.59) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6407017 | 0.79 | MEN1 (0.60) | DCTPP1ALDH1A1MAPTBCHEMEN1 | |
| SCHEMBL1545128 | 0.77 | ALDH1A1 (0.56) | LMNAALDH1A1MAPTMEN1MAPK1 | |
| SCHEMBL4214464 | 0.74 | LMNA (0.77) | LMNAALDH1A1MAPTMEN1MAPK1 | |
| SCHEMBL1544956 | 0.72 | HSD17B10 (0.64) | LMNAALDH1A1MAPTBCHEMEN1 | |
| SCHEMBL12836975 | 0.71 | PIK3CD (0.53) | ALDH1A1MAPTCYP11B1CYP11B2NPC1 | |
| SCHEMBL18556558 | 0.71 | LMNA (1.00) | LMNAALDH1A1MAPTMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359505-A1 | Dopamine-beta hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-03-21 | — | — | EP | disclosed |