Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 11/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12391806 | 1.00 | CTSS (0.46) | CTSSCTSKBACE1GLSATM | |
| SCHEMBL3495258 | 0.90 | CTSS (0.51) | CTSSCTSKBACE1GLSATM | |
| SCHEMBL3235114 | 0.90 | CTSS (0.51) | CTSSCTSKBACE1GLSATM | |
| SCHEMBL13494340 | 0.89 | AAK1 (0.49) | CTSSCTSKBACE1GLSATM | |
| SCHEMBL3232601 | 0.89 | AAK1 (0.49) | CTSSCTSKBACE1GLSATM | |
| SCHEMBL13941145 | 0.88 | GLS (0.45) | CTSSCTSKBACE1GLSATM | |
| SCHEMBL4750042 | 0.80 | CTSS (0.61) | CTSSCTSKBACE1 | |
| SCHEMBL8345117 | 0.76 | CTSS (0.51) | CTSSCTSKGLSATMMEN1 | |
| SCHEMBL8344155 | 0.76 | CTSS (0.51) | CTSSCTSKGLSATMMEN1 | |
| SCHEMBL8347951 | 0.76 | CTSS (0.51) | CTSSCTSKGLSATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008335-B2 | Indole and benzimidazole derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| EP-2275412-A1 | Indole and benzimidazole derivatives | Novartis Vaccines and Diagnostics, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| US-7662581-B1 | Eg5 co-crystals | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-7608723-B2 | N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-1H-benzimidazol-2-yl)-2-methylpropyl]-4-chlorobenzamide;kinesin spindle protein modulators; anticarcinogenic agents; in vivo stability, bio-availability; diagnosis/medical/;antitumor agents hyperplasia; restinosis; antiinflammatory agents; cardiac hypertrophy | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080317744-A1 | Indole and Benzimidazole Derivatives | CHIRON CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1807399-A2 | INDOLE AND BENZIMIDAZOLE DERIVATIVES | Novartis Vaccines and Diagnostics, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049835-A2 | INDOLE AND BENZIMIDAZOLE DERIVATIVES | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060084687-A1 | Indole and benzimidazole derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084687-A1 | Indole and benzimidazole derivatives | IDO1, IDO2, AADAC | CTSS 1701/4885CTSK 1471/4885BACE1 3093/4885 |
| US-20080317744-A1 | Indole and Benzimidazole Derivatives | IDO1, IDO2, AADAC | CTSS 1701/4885CTSK 1471/4885BACE1 3093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.