Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.45 |
| ▸ | METAP2 | P50579 | 4/20 | 0.41 |
| ▸ | METAP1 | P53582 | 3/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9177605 | 1.00 | REN (0.53) | RENSLC1A3SLC1A2SLC1A1METAP2 | |
| SCHEMBL7291539 | 1.00 | REN (0.53) | RENSLC1A3SLC1A2SLC1A1METAP2 | |
| SCHEMBL7317650 | 0.88 | REN (0.53) | RENMETAP2METAP1 | |
| SCHEMBL7317656 | 0.88 | REN (0.53) | RENMETAP2METAP1 | |
| SCHEMBL10589428 | 0.86 | SLC1A3 (0.41) | RENSLC1A3SLC1A2SLC1A1LTA4H | |
| SCHEMBL10587306 | 0.86 | SLC1A3 (0.41) | RENSLC1A3SLC1A2SLC1A1LTA4H | |
| SCHEMBL9575386 | 0.85 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL9685661 | 0.85 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL9858518 | 0.85 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL10588898 | 0.82 | SLC1A3 (0.38) | RENSLC1A3SLC1A2SLC1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369141-A1 | Aspartic protease inhibitors for the treatment of diseases caused by retroviruses | MERCK PATENT GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |