Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10534964 | 0.82 | HPGD (0.51) | HTR2CDRD2SPHK1DRD3PRMT5 | |
| SCHEMBL7844832 | 0.81 | HTR2C (0.72) | HTR2CDRD2HDAC4HDAC2HDAC8 | |
| SCHEMBL2571866 | 0.80 | SPHK1 (0.46) | HTR2CDRD2SPHK1DRD3PRMT5 | |
| Ammonia Solution, Strong SCHEMBL19664329 | 0.80 | HTR2C (0.70) | HTR2CDRD2HTR1AADRA1DADRA1A | |
| SCHEMBL2095198 | 0.80 | HTR2C (0.70) | HTR2CDRD2KMOHTR1AADRA1D | |
| SCHEMBL1515075 | 0.78 | HTR2C (0.72) | HTR2CDRD2HTR1AADRA1DADRA1A | |
| SCHEMBL3076838 | 0.77 | TSHR (0.45) | HTR2CDRD2HTR1AADRA1DADRA1A | |
| SCHEMBL13959717 | 0.77 | TAAR1 (0.47) | HTR2CDRD2SPHK1DRD3PRMT5 | |
| SCHEMBL7640849 | 0.77 | SPHK1 (0.50) | HTR2CDRD2SPHK1DRD3PRMT5 | |
| SCHEMBL8303700 | 0.77 | ALDH1A1 (0.40) | HTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385663-A2 | Heterocyclic cycloalkanes as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |