SCHEMBL8303700

SCHEMBL8303700

COCOc1cccc(C2OCCCO2)c1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
HTT P42858 1/20 0.40
CYP3A4 P08684 2/20 0.38
TSHR P16473 2/20 0.38
HIF1A Q16665 2/20 0.38
TP53 P04637 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
ATM Q13315 1/20 0.38
LMNA P02545 1/20 0.38
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
HTR2C P28335 3/20 0.35
HTR2A P28223 2/20 0.35
HTR2B P41595 2/20 0.35
DRD2 P14416 1/20 0.35
NR3C1 P04150 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9778641 0.81 MAOB (0.48) ALDH1A1SMN1; SMN2HTTCYP3A4TSHR
SCHEMBL3076838 0.80 TSHR (0.45) ALDH1A1SMN1; SMN2CYP3A4TSHRHIF1A
SCHEMBL767828 0.80 CYP3A4 (0.39) ALDH1A1SMN1; SMN2CYP3A4TSHRHIF1A
SCHEMBL20977574 0.78 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2HTTCYP3A4TSHR
SCHEMBL9778586 0.78 MAOB (0.54) ALDH1A1SMN1; SMN2HTTNPC1RAB9A
SCHEMBL10434809 0.77 HTR2C (0.50) HTR2CDRD2
SCHEMBL18063537 0.76 HTR2C (0.51) NPC1RAB9ALMNAHTR2CHTR2A
SCHEMBL28448305 0.73 DHFR (0.49) ALDH1A1SMN1; SMN2CYP3A4TSHRHIF1A
SCHEMBL10382898 0.73 DRD2 (0.39) ALDH1A1SMN1; SMN2CYP3A4TSHRHIF1A
SCHEMBL9778794 0.73 MAOA (0.48) ALDH1A1SMN1; SMN2TSHRNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0758312-B1 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS LILLY CO ELI (US) 1999-12-22 EP disclosed
EP-0758312-A4 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS LILLY CO ELI (US) 1997-09-10 EP disclosed
EP-0758312-A1 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS ELI LILLY AND COMPANY (US) 1997-02-19 EP disclosed
US-5583221-A ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS, VIRICIDES, FUNGICIDES ELI LILLY AND COMPANY (US) 1996-12-10 US disclosed
WO-1996005729-A1 VICINAL-SUBSTITUTED CARBOCYCLIC COMPOUNDS AS THERAPEUTIC AGENTS ELI LILLY AND COMPANY (US) 1996-02-29 WO disclosed
WO-1995030640-A1 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS ELI LILLY AND COMPANY (US) 1995-11-16 WO disclosed
US-5432198-A Enzyme inhibitors SPHINX PHARMACEUTICALS CORPORATION (US) 1995-07-11 US disclosed
US-4994486-A Neurological disorders ABBOTT LABORATORIES (US) 1991-02-19 US disclosed