Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4889866 | 1.00 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL104390 | 0.98 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL475574 | 0.98 | CA4 (0.73) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL2227442 | 0.95 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL73056 | 0.95 | CA4 (0.77) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL1303278 | 0.95 | CA4 (0.77) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL107371 | 0.95 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL11132767 | 0.95 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL761595 | 0.95 | CA4 (0.70) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL5471630 | 0.95 | CA4 (0.76) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372389-A1 | INHALATION FORMULATION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | LIU, ZHI (CN) | 2023-11-23 | — | — | US | claimed |
| CN-109195907-B | Activated carbon with high surface area and preparation method thereof | 爱德温工业公司 | 2023-07-25 | — | — | CN | claimed |
| CN-111803442-B | Stabilizer for improving bioavailability of ammonium glycyrrhetate S liquid dosage form and application thereof | 广州一品红制药有限公司 | 2022-06-14 | — | — | CN | claimed |
| WO-2022073459-A1 | INHALATION FORMULATION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 刘志 | 2022-04-14 | — | — | WO | claimed |
| CN-114306220-A | Inhalation preparation, preparation method and application thereof | 刘志 | 2022-04-12 | — | — | CN | claimed |
| US-11124418-B2 | Activated carbons with high surface areas and methods of making same | ADVEN INDUSTRIES, INC. (CA) | 2021-09-21 | — | — | US | claimed |
| CN-108589420-B | Low ignition tendency cigarette paper | 杭州华丰纸业有限公司 | 2021-05-11 | — | — | CN | claimed |
| CN-112741237-A | Concentrated fruit juice capable of keeping stable content of astragaloside and preparation method thereof | 甘肃陇萃堂营养保健食品股份有限公司 | 2021-05-04 | — | — | CN | claimed |
| CN-111803442-A | Stabilizer for improving bioavailability of ammonium glycyrrhetate S liquid dosage form and application thereof | 广州一品红制药有限公司 | 2020-10-23 | — | — | CN | claimed |
| EP-3687301-A1 | PARTICULATE ACIDULANT COMPOSITION COMPRISING MALIC ACID AND LACTIC ACID | Purac Biochem B.V. (NL) | 2020-08-05 | — | — | EP | claimed |
| US-20050148291-A1 | Polishing composition and polishing method | FUJIMI INCORPORATED (JP) | 2005-07-07 | — | — | US | claimed |
| US-6345634-B1 | COMPRISING OLEATE, ALCOHOL ETHOXYLATES, POLYCARBOXYLIC ACIDS AND BUFFERS ARE SPRAYED ONTO APPLES, LETTUCE AND THE LIKE TO REMOVE SOIL AND UNWANTED DEPOSITS. | THE PROCTER & GAMBLE COMPANY | 2002-02-12 | — | — | US | claimed |
| EP-0726717-B1 | CLEANING METHODS AND COMPOSITIONS FOR FOOD- AND FEEDSTUFF | PROCTER & GAMBLE (US) | 1999-01-07 | — | — | EP | claimed |
| US-5705461-A | SPRAY FOR FRUITS AND VEGETABLES INCLUDES ETHOXYLATED ALCOHOL, OLEIC ACID, AND POLYCARBOXYLIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 1998-01-06 | — | — | US | claimed |
| EP-0233110-B2 | Use of a salt to influence the flow characteristics of thickened compositions | RHONE POULENC CHIMIE (FR) | 1997-03-19 | — | — | EP | claimed |
| EP-0726717-A1 | CLEANING METHODS AND COMPOSITIONS FOR FOOD- AND FEEDSTUFF | THE PROCTER & GAMBLE COMPANY (US) | 1996-08-21 | — | — | EP | claimed |
| WO-1995012326-A1 | CLEANING METHODS AND COMPOSITIONS FOR FOOD- AND FEEDSTUFF | THE PROCTER & GAMBLE COMPANY (US) | 1995-05-11 | — | — | WO | claimed |
| US-4961927-A | Clear solution containing lysozyme hydrochloride and dipotassium glycyrrhizinate | EISAI CO., LTD. (JP) | 1990-10-09 | — | — | US | claimed |
| US-4819675-A | Chemical removal of dental plaque | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1989-04-11 | — | — | US | claimed |
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | claimed |