Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 12/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL27834300 | 0.97 | ALOX15 (0.43) | ALOX15BLMPMP22KMT2ADPP4 | |
| Glutamine SCHEMBL8392144 | 0.97 | ALOX15 (0.43) | ALOX15BLMPMP22KMT2ADPP4 | |
| Glutamine SCHEMBL20535489 | 0.96 | ALOX15 (0.37) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL27660739 | 0.93 | KMT2A (0.46) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| Glutamine SCHEMBL4667538 | 0.93 | KMT2A (0.46) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| Glutamine SCHEMBL10428552 | 0.92 | ALOX15 (0.34) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL5664831 | 0.91 | ALOX15 (0.44) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| Glutamine SCHEMBL6853199 | 0.91 | ALOX15 (0.44) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| D-Glutamate SCHEMBL28397750 | 0.89 | GRM8 (0.33) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL3054141 | 0.89 | ALOX15 (0.42) | ALOX15BLMPMP22KMT2ASLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0366239-A1 | Purification process for recombinant influenza proteins | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-02 | — | — | EP | disclosed |
| EP-0366238-A2 | Influenza vaccinal polypeptides | SMITHKLINE BEECHAM CORPORATION (US) | 1990-05-02 | — | — | EP | disclosed |