Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL10439261 | 0.96 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL18954801 | 0.94 | ALOX15 (0.42) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL18954804 | 0.94 | ALOX15 (0.42) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL27834300 | 0.93 | ALOX15 (0.43) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL8392144 | 0.93 | ALOX15 (0.43) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL4398683 | 0.90 | ALOX15 (0.39) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL4667538 | 0.90 | KMT2A (0.46) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL27660739 | 0.90 | KMT2A (0.46) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL4595490 | 0.89 | ALOX15 (0.38) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL10428552 | 0.88 | ALOX15 (0.34) | ALOX15BLMPMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190093096-A1 | COMOSAIN AND BROMELAINS AS IMMUNO-THERAPY IN THE TREATING AND/OR PREVENTING VARIOUS TYPES OF CANCER IN A MAMMAL | LIAO, ALEX BISMARK (US) | 2019-03-28 | — | — | US | disclosed |
| WO-2018190783-A1 | THE CLONING AND EXPRESSION OF COMOSAIN'S MINIGENE, AND AS IMMUNO-TARGET CHEMOTHERAPEUTIC AGENTS IN TREATING AND OR PREVENTING VARIOUS TYPES OF CANCER IN MAMMALS | LIAO BENEDICT SCHUE (US) | 2018-10-18 | — | — | WO | disclosed |