Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830821 | 0.92 | LMNA (0.45) | POLBTSHRSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL9830815 | 0.92 | LMNA (0.45) | POLBTSHRSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL9828908 | 0.85 | KDM4E (0.51) | POLBTSHRL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL9828915 | 0.85 | KDM4E (0.51) | POLBTSHRL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL193093 | 0.82 | KCNN4 (0.44) | TSHRL3MBTL1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL5711399 | 0.82 | MEN1 (0.51) | POLBL3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL31329451 | 0.81 | CXCR2 (0.39) | CYP1A2HPGDALDH1A1GAAMEN1 | |
| SCHEMBL29897721 | 0.79 | POLB (0.49) | POLBTSHRTDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7319974 | 0.78 | CA12 (0.43) | L3MBTL1CYP2C19RAB9ANPC1GAA | |
| SCHEMBL27158981 | 0.78 | CA12 (0.43) | L3MBTL1CYP2C19RAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0386839-A2 | Tetrahydroquinoline derivatives useful for neurodegenerative disorders | MERCK SHARP & DOHME LTD. (GB) | 1990-09-12 | — | — | EP | disclosed |