Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.30 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.30 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.30 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.30 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.30 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15864983 | 1.00 | HTR1A (0.40) | HTR1ACA2L3MBTL1MAPK1F2RL3 | |
| SCHEMBL15865373 | 0.84 | HTR1A (0.43) | HTR1ACA2F2RL3PRKAB2PRKAG1 | |
| SCHEMBL15865376 | 0.84 | HTR1A (0.43) | HTR1ACA2F2RL3PRKAB2PRKAG1 | |
| SCHEMBL1021998 | 0.84 | CA2 (0.36) | HTR1ACA2L3MBTL1MAPK1F2RL3 | |
| SCHEMBL1019142 | 0.84 | CA2 (0.36) | HTR1ACA2L3MBTL1MAPK1F2RL3 | |
| SCHEMBL15864981 | 0.84 | HTR1A (0.47) | HTR1ACA2L3MBTL1MAPK1F2RL3 | |
| SCHEMBL15864979 | 0.84 | HTR1A (0.47) | HTR1ACA2L3MBTL1MAPK1F2RL3 | |
| SCHEMBL1042558 | 0.82 | CA2 (0.41) | HTR1ACA2DRD2HPGDTSHR | |
| SCHEMBL15865515 | 0.81 | HTR1A (0.35) | HTR1ACA2L3MBTL1MAPK1 | |
| SCHEMBL15865514 | 0.81 | HTR1A (0.35) | HTR1ACA2L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941427-B1 | NOVEL BENZODIOXANE-PIPERIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | PF MEDICAMENT (FR) | 2016-11-09 | — | — | EP | disclosed |
| US-20150336943-A1 | NOVEL BENZODIOXANE-PIPERIDINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS FOR TREATING NEUROPSYCHIATRIC DISORDERS | PIERRE FABRE MEDICAMENT (FR) | 2015-11-26 | — | — | US | disclosed |
| EP-2941427-A1 | NOVEL BENZODIOXANE-PIPERIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | Pierre Fabre Médicament (FR) | 2015-11-11 | — | — | EP | disclosed |
| WO-2014106660-A1 | NOVEL BENZODIOXANE-PIPERIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | PIERRE FABRE MEDICAMENT (FR) | 2014-07-10 | — | — | WO | disclosed |
| US-20110105462-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-05-05 | — | — | US | disclosed |
| EP-2271635-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, Filial af NeuroSearch Sweden AB, Sverige (DK) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009133109-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105462-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | DBH, SLC18A2, SLC6A3 | HTR1A 54/4885CA2 3728/4885L3MBTL1 4244/4885 |
| US-20150336943-A1 | NOVEL BENZODIOXANE-PIPERIDINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS FOR TREATING NEUROPSYCHIATRIC DISORDERS | HCRTR1, HCRTR2, OXSR1 | HTR1A 41/4885CA2 4017/4885L3MBTL1 1697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.