SCHEMBL104446

SCHEMBL104446

CCCC=C1CCCCC1

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DPP7 Q9UHL4 2/20 0.39
ABCB1 P08183 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11303483 1.00 DPP7 (0.39) DPP7ABCB1
SCHEMBL27150404 1.00 DPP7 (0.39) DPP7ABCB1
SCHEMBL27137288 1.00 DPP7 (0.39) DPP7ABCB1
SCHEMBL11299622 1.00 DPP7 (0.39) DPP7ABCB1
SCHEMBL102512 0.97
SCHEMBL27143448 0.92
SCHEMBL28175746 0.88 DPP7 (0.31) DPP7ABCB1
SCHEMBL29187652 0.86 TSHR (0.33)
SCHEMBL1792180 0.86
SCHEMBL8959083 0.85 ABCB1 (0.37) DPP7ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0354040-A2 Membranes prepared from blends of polybenzimidazole with polyarylates HOECHST CELANESE CORPORATION (US) 1990-02-07 EP claimed
WO-2024043341-A1 CYCLOALKYNE DERIVATIVE ペプチドリーム株式会社 2024-02-29 WO disclosed
EP-1641759-B1 MALONAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2014-03-12 EP disclosed
EP-1643991-B1 BENZIMIDAZOLE CARBOXAMIDES AS RAF KINASE INHIBITORS MERCK PATENT GMBH (DE) 2014-03-12 EP disclosed
US-20130158076-A1 Methylene Urea Derivatives MERCK PATENT GMBH (DE) 2013-06-20 US disclosed
US-8410143-B2 Methylene urea derivatives MERCK PATENT GMBH (DE) 2013-04-02 US disclosed
EP-2426122-A1 Methylene urea derivative as RAF kinasse inhibitors Merck Patent GmbH (DE) 2012-03-07 EP disclosed
EP-1653951-B1 BENZIMIDAZOLE DERIVATIVES AS RAF KINASE INHIBITORS MERCK PATENT GMBH (DE) 2011-12-28 EP disclosed
US-8003657-B2 Heterocyclic substituted bisarylurea derivatives MERCK PATENT GMBH (DE) 2011-08-23 US disclosed
EP-1343769-B1 BENZOYLPYRIDAZINES MERCK PATENT GMBH (DE) 2010-08-04 EP disclosed
WO-2003008392-A1 4-(BENZYLIDENE-AMINO)-3-(METHYLSULFANYL)-4H-(1, 2, 4) TRIAZIN-5-ONE DERIVATIVES HAVING A PDE-IV INHIBITING AND TNF-ANTAGONISTIC EFFECT FOR THE TREATMENT OF CARDIAC DISEASES AND ALLERGIES MERCK PATENT GMBH (DE) 2003-01-30 WO disclosed
US-6417188-B1 ENZYME INHIBITORS OF PHOSPHODIESTERASE MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2002-07-09 US disclosed
WO-2002051814-A1 BENZOYLPYRIDAZINES MERCK PATENT GMBH (DE) 2002-07-04 WO disclosed
EP-1194411-A1 BENZOYLPYRIDAZINES MERCK PATENT GmbH (DE) 2002-04-10 EP disclosed
EP-1173438-A1 SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2002-01-23 EP disclosed
EP-1087946-A1 ARYL ALKANOYLPYRIDAZINES MERCK PATENT GmbH (DE) 2001-04-04 EP disclosed
WO-2001004099-A1 BENZOYLPYRIDAZINES MERCK PATENT GMBH (DE) 2001-01-18 WO disclosed
WO-2000063208-A1 SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2000-10-26 WO disclosed
WO-1999065880-A1 ARYL ALKANOYLPYRIDAZINES MERCK PATENT GMBH (DE) 1999-12-23 WO disclosed
US-4791149-A MIXING AND DISPENSING BY A PROPELLANT HYDROSILATION-CURABLE POLYSILOXANES AND A CATALYST FROM A MULTICOMPARTMENT PACKAGE DOW CORNING FRANCE S.A. (FR) 1988-12-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130158076-A1 Methylene Urea Derivatives BRAF, RAF1, CMPK1 DPP7 3734/4885ABCB1 1078/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.