Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770286 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL10323079 | 0.83 | TNF (0.62) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL10323080 | 0.83 | TNF (0.62) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL14587405 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL5834090 | 0.81 | CASP3 (0.53) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL7340237 | 0.80 | ALDH1A1 (0.48) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL7343840 | 0.80 | TNF (0.52) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL10448820 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL12898667 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HSD17B10L3MBTL1TNFPOLB | |
| SCHEMBL16322141 | 0.79 | MEN1 (0.58) | ALDH1A1HSD17B10L3MBTL1TNFPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | ALDH1A1 2619/4885HSD17B10 4275/4885L3MBTL1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.