Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343840 | 0.84 | TNF (0.52) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL10323079 | 0.80 | TNF (0.62) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL14587405 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL10447019 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL4770286 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL10323080 | 0.80 | TNF (0.62) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL5834090 | 0.79 | CASP3 (0.53) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL10568655 | 0.76 | ALDH1A1 (0.68) | ALDH1A1HSD17B10L3MBTL1KDM4ETP53 | |
| SCHEMBL10448820 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E | |
| SCHEMBL16322141 | 0.76 | MEN1 (0.58) | ALDH1A1HSD17B10L3MBTL1TNFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252928-A1 | PHOSPHINYLALKANOYL IMINO ACIDS | SCHERING CORPORATION (US) | 1988-01-20 | — | — | EP | disclosed |
| EP-0224067-A1 | Phosphinylalkanoyl amino acids | SCHERING CORPORATION (US) | 1987-06-03 | — | — | EP | disclosed |
| WO-1987002669-A1 | PHOSPHINYLALKANOYL IMINO ACIDS | SCHERING CORPORATION (US) | 1987-05-07 | — | — | WO | disclosed |
| US-4634689-A | HYPOTENSIVE AGENTS | SCHERING CORPORATION (US) | 1987-01-06 | — | — | US | disclosed |