Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10481806 | 0.82 | CA1 (0.44) | CA1CA2MAPK1ACE2FDPS | |
| SCHEMBL8169390 | 0.81 | CA1 (0.47) | CA1CA2MAPK1ACE2FDPS | |
| SCHEMBL3517874 | 0.80 | CA1 (0.45) | CA1CA2MAPK1ACE2FDPS | |
| SCHEMBL3517878 | 0.80 | CA1 (0.45) | CA1CA2MAPK1ACE2FDPS | |
| SCHEMBL3831921 | 0.78 | CA1 (0.53) | CA1ACE2FDPSFFAR1FFAR4 | |
| SCHEMBL21436875 | 0.78 | CA1 (0.57) | CA1ACE2FDPSFFAR1FFAR4 | |
| SCHEMBL21436874 | 0.78 | CA1 (0.57) | CA1ACE2FDPSFFAR1FFAR4 | |
| SCHEMBL28323830 | 0.76 | CA1 (0.55) | CA1ACE2FDPSFFAR1FFAR4 | |
| SCHEMBL9322240 | 0.74 | ALDH1A1 (0.36) | — | |
| Bromide SCHEMBL7118673 | 0.74 | ACE2 (0.49) | CA1ACE2FDPSFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185380-B1 | THIOL BASED COLLAGENASE INHIBITORS | G.D. Searle & Co. (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4681966-A | ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1987-07-21 | — | — | US | disclosed |
| EP-0185380-A2 | Thiol based collagenase inhibitors | G.D. Searle & Co. (US) | 1986-06-25 | — | — | EP | disclosed |
| US-4595700-A | Thiol based collagenase inhibitors | G. D. SEARLE & CO. (US) | 1986-06-17 | — | — | US | disclosed |