SCHEMBL10453055

SCHEMBL10453055

CN(C)Cc1c(C(C)(C)C)cccc1C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.44
ALDH1A1 P00352 4/20 0.44
TSHR P16473 3/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
MAPT P10636 2/20 0.37
CYP3A4 P08684 1/20 0.37
KDM4E B2RXH2 2/20 0.37
KMT2A Q03164 2/20 0.37
CYP2D6 P10635 1/20 0.36
HRH3 Q9Y5N1 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRNA7 P36544 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26652074 0.88 GABRA1 (0.47) CA2ALDH1A1TSHRLMNAGAA
SCHEMBL22380057 0.86 ALDH1A1 (0.43) CA2ALDH1A1TSHRLMNAGAA
SCHEMBL28234180 0.76 CA2 (0.48) CA2ALDH1A1TSHRGAAGABRA1
SCHEMBL8310680 0.76 CYP2C19 (0.46) ALDH1A1TSHRLMNAGAACYP1A2
SCHEMBL8636370 0.75 CA2 (0.52) CA2ALDH1A1TSHRLMNAGAA
SCHEMBL11578283 0.74 ALDH1A1 (0.55) CA2ALDH1A1TSHRLMNAGAA
SCHEMBL677479 0.71 CA2 (0.48) CA2ALDH1A1TSHRGAAGABRA1
SCHEMBL105826 0.71 CA2 (0.54) CA2ALDH1A1TSHRLMNAGAA
SCHEMBL24425088 0.70 CYP2D6 (0.39) CA2ALDH1A1TSHRLMNAGAA
SCHEMBL12771997 0.70 CYP1A2 (0.38) CA2ALDH1A1TSHRLMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4954275-A AND POLYMERS CIBA-GEIGY CORPORATION (US) 1990-09-04 US disclosed
US-4889883-A POLYBUTADIENE, POLYISOPRENE, NEOPRENE, STYRENE BLOCK POLYMERS; LUBRICANTS CIBA-GEIGY CORPORATION (US) 1989-12-26 US disclosed
EP-0059168-B1 ORGANIC ELASTOMERS AND MINERAL AND SYNTHETIC LUBRICATING OILS CONTAINING PHENOLMERCAPTOCARBOXYLIC ESTERS AS STABILIZERS CIBA-GEIGY AG (CH) 1985-10-02 EP disclosed
EP-0059168-A1 Organic elastomers and mineral and synthetic lubricating oils containing phenolmercaptocarboxylic esters as stabilizers CIBA-GEIGY AG (CH) 1982-09-01 EP disclosed