Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10452882 | 0.99 | KDM4E (0.57) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10452925 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10452829 | 0.93 | KDM4E (0.61) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10453668 | 0.88 | MAPT (0.43) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10454132 | 0.88 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10454122 | 0.87 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10453889 | 0.87 | MAPT (0.44) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL11614996 | 0.87 | CASP3 (0.40) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10453751 | 0.86 | XDH (0.42) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10454133 | 0.86 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902701-A | Tetrazolyl substituted tricyclic compounds and pharmacological compositions thereof | BURROUGHS WELCOME CO. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0093381-B1 | TRICYCLIC COMPOUNDS, PREPARATION, USE AND INTERMEDIATES | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |
| EP-0093381-A1 | Tricyclic compounds, preparation, use and intermediates | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-11-09 | — | — | EP | disclosed |