Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 4/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10454526 | 0.90 | GRIK1 (0.47) | GRIK1GRIA2EPHX2KCNH2RAB9A | |
| SCHEMBL10455761 | 0.89 | P2RX7 (0.43) | GRIK1GRIA2EPHX2KCNH2RAB9A | |
| SCHEMBL10455519 | 0.89 | P2RX7 (0.43) | GRIK1GRIA2EPHX2KCNH2RAB9A | |
| SCHEMBL10455774 | 0.89 | P2RX7 (0.43) | GRIK1GRIA2EPHX2KCNH2RAB9A | |
| SCHEMBL10455763 | 0.85 | RORC (0.41) | GRIK1GRIA2AKR1C3AKR1C1S1PR5 | |
| SCHEMBL10455807 | 0.83 | GRIK1 (0.41) | GRIK1GRIA2 | |
| SCHEMBL10454505 | 0.81 | GRIK1 (0.44) | GRIK1GRIA2EPHX2KCNH2RAB9A | |
| SCHEMBL10455805 | 0.81 | S1PR5 (0.42) | GRIK1GRIA2EPHX2KCNH2AKR1C3 | |
| SCHEMBL10455809 | 0.80 | EPHX2 (0.43) | EPHX2KCNH2RORCOPRK1 | |
| SCHEMBL10455655 | 0.79 | AR (0.42) | GRIK1GRIA2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210772-B1 | 3-[(4-Aroyl)phenoxy(or phenylthio)]cyclopentanecarboxylic acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-06-06 | — | — | EP | claimed |
| EP-0210772-B1 | 3-[(4-Aroyl)phenoxy(or phenylthio)]cyclopentanecarboxylic acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-06-06 | — | — | EP | disclosed |
| US-4916147-A | 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic acid analogues and treatment of cerebral edema therewith | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-04-10 | — | — | US | disclosed |