SCHEMBL10458080

SCHEMBL10458080

CCc1ccc2ccc(C(=O)C(C)(C)C)cc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.47
CYP1A2 P05177 1/20 0.47
ALDH1A1 P00352 2/20 0.43
AKR1C3 P42330 1/20 0.43
AKR1C2 P52895 1/20 0.43
RIOK2 Q9BVS4 1/20 0.40
F2 P00734 1/20 0.40
PLG P00747 1/20 0.40
PLAU P00749 1/20 0.40
PLAT P00750 1/20 0.40
KLKB1 P03952 1/20 0.40
PRSS1 P07477 1/20 0.40
PLK1 P53350 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.38
HPGD P15428 1/20 0.38
BCL2 P10415 1/20 0.37
GRIN2D O15399 1/20 0.37
GRIN2A Q12879 1/20 0.37
GRIN2B Q13224 1/20 0.37
GRIN2C Q14957 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10458493 0.95 CYP1A2 (0.48) CYP2A6CYP1A2ALDH1A1AKR1C3AKR1C2
SCHEMBL10458014 0.81 CYP2A6 (0.59) CYP2A6CYP1A2ALDH1A1AKR1C3AKR1C2
SCHEMBL1628100 0.80 ALDH1A1 (0.59) CYP1A2ALDH1A1PLK1SMN1; SMN2HPGD
SCHEMBL16722810 0.80 CES2 (0.46) CYP2A6ALDH1A1PLAUSMN1; SMN2HPGD
SCHEMBL10457821 0.79 CYP1A2 (0.50) CYP2A6CYP1A2ALDH1A1AKR1C3AKR1C2
SCHEMBL10456610 0.77 CYP2A6 (0.65) CYP2A6CYP1A2ALDH1A1SMN1; SMN2NPC1
SCHEMBL855148 0.77 KAT6A (0.48) BCL2GRIN2BACHE
SCHEMBL855617 0.77 CES2 (0.61) ALDH1A1F2PLGPLAUKLKB1
SCHEMBL10457997 0.77 AKR1C3 (0.50) CYP2A6CYP1A2ALDH1A1AKR1C3AKR1C2
SCHEMBL29475635 0.75 CYP2A6 (0.76) CYP2A6CYP1A2ALDH1A1AKR1C3AKR1C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4935537-A OXIDIZING ACYLALKYLNAPHTHALENE WITH PEROXIDE, OXIDIZING PRODUCT WITH OXYGEN USING CATALYST CONTAINING COBALT AND BROMINE COMPOUNDS MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1990-06-19 US disclosed
US-4801737-A Process for producing acyloxynaphthoic acids MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1989-01-31 US disclosed
EP-0170273-B1 PROCESS FOR PRODUCING ACYLOXYNAPHTHOIC ACIDS MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1988-12-28 EP disclosed
EP-0170273-A2 Process for producing acyloxynaphthoic acids MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1986-02-05 EP disclosed