SCHEMBL1046022

SCHEMBL1046022

C=C(C)C(=O)OCC1(C)CC[Si](C)(C)[Si](C)(C)O1

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.37
TSHR P16473 3/20 0.34
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11324745 0.86 ALDH1A1 (0.30) ALDH1A1
SCHEMBL9411490 0.84 ALDH1A1 (0.38) ALDH1A1TSHRTHRB
SCHEMBL216519 0.83 TSHR (0.41) ALDH1A1TSHRTHRB
SCHEMBL1274404 0.79 ALDH1A1 (0.37) ALDH1A1TSHRTHRB
Acrylamide SCHEMBL28093276 0.77 TSHR (0.35) TSHRTHRB
SCHEMBL1356853 0.76 ALDH1A1 (0.44) ALDH1A1TSHRTHRB
SCHEMBL714093 0.76 TSHR (0.48) ALDH1A1TSHRTHRB
SCHEMBL16859715 0.74 ALDH1A1 (0.31) ALDH1A1TSHR
SCHEMBL704975 0.73 TSHR (0.42) ALDH1A1TSHRTHRB
SCHEMBL2878361 0.72 ALDH1A1 (0.41) ALDH1A1TSHRTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4818801-A IMPROVED OXYGEN PERMEABILITY; CONTACT LENSES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-04-04 US claimed
US-4543398-A Ophthalmic devices fabricated from urethane acrylates of polysiloxane alcohols MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-09-24 US claimed
EP-0127321-A1 Ophthalmic devices fabricated from urethane acrylates of polysiloxane alcohols MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1984-12-05 EP claimed
US-4440918-A OXYGEN PERMEABILITY MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1984-04-03 US claimed
US-4246389-A ACRYLIC SILOXANES COPOLYMERIZED WITH HYDROXY ETHYL METHACRYLATE AND VINYL PYRROLIDONE AMERICAN OPTICAL CORPORATION (US) 1981-01-20 US claimed
US-4152508-A OXYGEN PERMEABILITY, DIMENSIONAL STABILITY POLYMER TECHNOLOGY CORPORATION (US) 1979-05-01 US claimed
US-11874434-B2 Ophthalmic devices comprising photochromic materials with reactive substituents JOHNSON & JOHNSON VISION CARE, INC. (US) 2024-01-16 US disclosed
US-20220137262-A1 OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS JOHNSON & JOHNSON VISION CARE (US) 2022-05-05 US disclosed
US-11256002-B2 Ophthalmic devices comprising photochromic materials with reactive substituents JOHNSON & JOHNSON VISION CARE, INC. (US) 2022-02-22 US disclosed
EP-3633423-A1 OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS Johnson & Johnson Vision Care, Inc. (US) 2020-04-08 EP disclosed
CN-104898187-B Ophthalmic devices comprising photochromic materials having reactive substituents INNOTECH, INC., JOHNSON AND JOHNSON VISION CARE (US) 2019-12-10 CN disclosed
EP-1872159-B1 OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS JOHNSON AND JOHNSON VISION CARE INC (US) 2019-09-04 EP disclosed
US-20190129067-A1 OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS JOHNSON & JOHNSON VISION CARE (US) 2019-05-02 US disclosed
WO-1986004342-A1 OXYGEN-PERMEABLE LENSES BAUSCH AND LOMB INCORPORATED (US) 1986-07-31 WO disclosed
US-4543398-A Ophthalmic devices fabricated from urethane acrylates of polysiloxane alcohols MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-09-24 US disclosed
EP-0127321-A1 Ophthalmic devices fabricated from urethane acrylates of polysiloxane alcohols MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1984-12-05 EP disclosed
US-4440918-A OXYGEN PERMEABILITY MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1984-04-03 US disclosed
EP-0016138-B1 HYDROPHILIC, SOFT AND OXYGEN PERMEABLE COPOLYMER COMPOSITIONS CHANG, Sing-Hsiung (US) 1983-11-09 EP disclosed
EP-0084406-A1 Ophthalmic device comprising a polymer of a telechelic perfluoropolyether MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1983-07-27 EP disclosed
US-4246389-A ACRYLIC SILOXANES COPOLYMERIZED WITH HYDROXY ETHYL METHACRYLATE AND VINYL PYRROLIDONE AMERICAN OPTICAL CORPORATION (US) 1981-01-20 US disclosed