Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10461397 | 0.94 | KDM4E (0.58) | DRD2HTR1AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10560791 | 0.94 | DRD2 (0.57) | DRD2HTR1AHTR7CACNA1GSLC6A2 | |
| Oxalic Acid SCHEMBL10460865 | 0.93 | KMT2A (0.56) | DRD2KDM4EALDH1A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL10460396 | 0.90 | SLC6A2 (0.56) | DRD2KDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10559724 | 0.88 | HTR2A (0.56) | DRD2HTR1AHTR7SLC6A3 | |
| SCHEMBL10560937 | 0.87 | HTR2A (0.55) | DRD2HTR1AHTR7SLC6A3 | |
| SCHEMBL10556014 | 0.87 | HTR2A (0.55) | DRD2HTR1AHTR7SLC6A3ALDH1A1 | |
| Fumaric Acid SCHEMBL10461365 | 0.86 | DRD2 (0.51) | DRD2HTR1A | |
| Fumaric Acid SCHEMBL10461367 | 0.86 | DRD2 (0.51) | DRD2HTR1A | |
| SCHEMBL10560753 | 0.85 | TMEM97 (0.59) | TDP1HTR1AHTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4950674-A | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-21 | — | — | US | disclosed |
| US-4810713-A | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |