Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10557081 | 0.89 | PAX8 (0.60) | KCNH2MEN1PAX8HRH1HTR1A | |
| SCHEMBL8536666 | 0.88 | KCNH2 (0.57) | KCNH2MEN1PAX8HRH1 | |
| SCHEMBL10461458 | 0.86 | KCNH2 (0.53) | KCNH2CYP2D6CYP2C19MEN1PAX8 | |
| SCHEMBL10461068 | 0.85 | MAPT (0.57) | KCNH2MEN1PAX8HRH1CYP2J2 | |
| SCHEMBL10460949 | 0.85 | KCNH2 (0.73) | KCNH2MEN1PAX8HRH1HTR1A | |
| SCHEMBL10461612 | 0.85 | KCNH2 (0.57) | KCNH2MEN1PAX8HRH1 | |
| SCHEMBL10459172 | 0.84 | ABCB11 (0.50) | KCNH2PAX8HRH1HTR1ACYP2J2 | |
| SCHEMBL10558297 | 0.84 | PAX8 (0.54) | KCNH2MEN1PAX8HRH1CYP2J2 | |
| SCHEMBL10461861 | 0.83 | KCNH2 (0.70) | KCNH2MEN1PAX8HTR1A | |
| SCHEMBL30357958 | 0.83 | MEN1 (0.50) | KCNH2MEN1HRH1HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4950674-A | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-21 | — | — | US | disclosed |