Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.48 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.48 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CPA3 | P15088 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650877 | 0.97 | EPHX1 (0.55) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| Bromide SCHEMBL11187003 | 0.85 | EPHX1 (0.50) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL28505261 | 0.82 | EPHX1 (0.46) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL6720552 | 0.82 | ACE (0.54) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL7477751 | 0.82 | EPHX1 (0.46) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL11188256 | 0.82 | EPHX1 (0.52) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL9122735 | 0.82 | TRPA1 (0.54) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL8711135 | 0.80 | EPHX1 (0.55) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL4133548 | 0.79 | EPHX1 (0.48) | EPHX1ANPEPTAAR1SLC6A2SIGMAR1 | |
| SCHEMBL10963242 | 0.79 | ACE (0.47) | EPHX1TAAR1SLC6A2SIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530617-B2 | Silicon-containing particle, process for producing the same, organic-polymer composition, ceramic, and process for producing the same | DOW CORNING TORAY COMPANY, LTD. (JP) | 2013-09-10 | — | — | US | disclosed |
| US-8450231-B2 | Silicon-containing particles, method for manufacturing thereof, oil composition, ceramic material, and method for manufacturing thereof | DOW CORNING TORAY COMPANY, LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| EP-2143718-B1 | PROCESS FOR PRODUCING TETRAGLYCIDYLAMINO COMPOUND | MITSUBISHI GAS CHEMICAL CO (JP) | 2012-11-21 | — | — | EP | disclosed |
| EP-2461397-A1 | ELECTRODE ACTIVE MATERIAL, ELECTRODE, AND ELECTRICITY STORAGE DEVICE | Dow Corning Toray Co., Ltd. (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20120121981-A1 | Electrode Active Material, Electrode, And Electricity Storage Device | DOW CORNING TORAY CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-8039650-B2 | Process for producing tetraglycidylamino compound | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2011-10-18 | — | — | US | disclosed |
| US-20110045963-A1 | Silicon-Containing Particles, Method For Manufacturing Thereof, Oil Composition, Ceramic Material, And Method For Manufacturing Thereof | DOW CORNING TORAY COMPANY, LTD. (JP) | 2011-02-24 | — | — | US | disclosed |
| US-20110033708-A1 | Silicon-Containing Particle, Process For Producing The Same, Organic-Polymer Composition, Ceramic, And Process For Producing The Same | DOW CORNING TORAY COMPANY, LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
| EP-2271702-A2 | SILICON-CONTAINING PARTICLES, METHOD FOR MANUFACTURING THEREOF, OIL COMPOSITION, CERAMIC MATERIAL, AND METHOD FOR MANUFACTURING THEREOF | Dow Corning Toray Co., Ltd. (JP) | 2011-01-12 | — | — | EP | disclosed |
| EP-2241586-A1 | SILICON-CONTAINING PARTICLE, PROCESS FOR PRODUCING THE SAME, ORGANIC-POLYMER COMPOSITION, CERAMIC, AND PROCESS FOR PRODUCING THE SAME | Dow Corning Toray Co., Ltd. (JP) | 2010-10-20 | — | — | EP | disclosed |
| US-20100222604-A1 | PROCESS FOR PRODUCING TETRAGLYCIDYLAMINO COMPOUND | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2010-09-02 | — | — | US | disclosed |
| EP-2143718-A1 | PROCESS FOR PRODUCING TETRAGLYCIDYLAMINO COMPOUND | Mitsubishi Gas Chemical Company, Inc. (JP) | 2010-01-13 | — | — | EP | disclosed |
| WO-2009133765-A2 | SILICON-CONTAINING PARTICLES, METHOD FOR MANUFACTURING THEREOF, OIL COMPOSITION, CERAMIC MATERIAL, AND METHOD FOR MANUFACTURING THEREOF | DOW CORNING TORAY CO., LTD. (JP) | 2009-11-05 | — | — | WO | disclosed |
| EP-0287249-B1 | A PROCESS FOR PRODUCING A POLYGLYCIDYLAMINO COMPOUND | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1992-03-04 | — | — | EP | disclosed |
| US-4871867-A | DEHYDROHALOGENATION; REACTING CARBOCYCLIC DIAMINE WITH EPIHALOHYDRIN | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1989-10-03 | — | — | US | disclosed |
| EP-0287249-A1 | A process for producing a polyglycidylamino compound | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1988-10-19 | — | — | EP | disclosed |
| US-4373073-A | Process for the preparation of glycidyl ethers of monohydric or polyhydric phenols, the glycidyl ethers and use thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-02-08 | — | — | US | disclosed |
| US-3948916-A | HYDANTOINS OR URACILS, POLYEPOXIDES | CIBA-GEIGY AG (CH) | 1976-04-06 | — | — | US | disclosed |
| US-3931058-A | POLYGLYCIDYL COMPOUNDS, PROCESSES FOR THEIR MANUFACTURE AND USE | CIBA-GEIGY AG (CH) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222604-A1 | PROCESS FOR PRODUCING TETRAGLYCIDYLAMINO COMPOUND | AGL, TREH, APEH | SLC6A2 2961/4885SIGMAR1 4280/4885SLC6A4 2617/4885 |
| US-20110033708-A1 | Silicon-Containing Particle, Process For Producing The Same, Organic-Polymer Composition, Ceramic, And Process For Producing The Same | SKP1, SPOP, SSRP1 | SLC6A2 4863/4885SIGMAR1 2671/4885SLC6A4 4789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.